Dapoxetine

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Dapoxetine 30mg/60mg/90mg Tablets Online

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Dapoxetine, commonly referred to by its brand name Priligy, belongs to a class of medications known as Selective Serotonin Reuptake Inhibitors (SSRIs). This pharmaceutical product is primarily prescribed to address erectile dysfunction, a condition characterized by a man's inability to delay ejaculation during sexual activity. Each Dapoxetine tablet is round and its color may vary based on the specific brand.

Uses of Dapoxetine

This effective medication is specifically designed for the management of premature ejaculation in men aged 18 – 64 who manifest the following symptoms:

  • Persistent difficulty in controlling ejaculation, which is often defined by recurrent episodes of ejaculation occurring with minimal sexual stimulation prior to, during, or shortly after vaginal penetration against the individual's will.
  • Ejaculation occurring within two minutes of vaginal penetration, known clinically as an intravaginal ejaculatory latency time of less than 2 minutes.
  • Significant psychological distress that is linked to experiencing premature ejaculation.

How Does Dapoxetine Work

As an SSRI, Dapoxetine operates by inhibiting the serotonin transporter, which is pivotal in managing ejaculatory signals. By blocking the reuptake of serotonin, the medication enhances the duration of serotonin's action on the postsynaptic receptors. This mechanism not only prolongs the time to ejaculation but also promotes better control over ejaculation timing.

Precautions

Please ensure you read the following precautions thoroughly before commencing treatment with this medication. If you have any personal health concerns about the safety of Dapoxetine, it is crucial that you consult with a healthcare professional before use.

Notify your healthcare provider if you have any known allergies to Dapoxetine or other similar compounds. You should also disclose your medical history, particularly if you have had:

  • Significant heart disorders, including arrhythmias or heart failure;
  • Bleeding disorders or issues related to blood clotting;
  • History of fainting spells;
  • Conditions leading to increased eye pressure, such as glaucoma;
  • Moderate to severe liver disease;
  • Chronic kidney issues;
  • Epileptic conditions;
  • Mental health disorders, including but not limited to mania, depression, or bipolar disorder;
  • Any history of alcoholism;
  • Substance abuse issues;
  • Current or recent treatment with monoamine oxidase inhibitors (MAOIs) within the last two weeks.

This medication is not intended for individuals below the age of 18 and is also contraindicated in pregnant or nursing women.

Due to the potential effects of Dapoxetine, such as dizziness or drowsiness, it is advisable to refrain from driving or operating heavy machinery during treatment.

Additionally, the use of alcohol while on Dapoxetine may exacerbate feelings of dizziness or drowsiness.

Avoid consuming grape juice within 24 hours before taking Dapoxetine, as it can significantly elevate the levels of Dapoxetine hydrochloride in your bloodstream.

This medication should only be taken if you have been clinically diagnosed with erectile dysfunction.

Dapoxetine Dosage and Administration

Dapoxetine is administered orally, with or without food. To mitigate the bitterness of the tablet, it is recommended to swallow it whole with a generous amount of water. It is essential to take Dapoxetine only as needed.

The standard recommended dosage is 30 mg (one tablet), taken 1 – 3 hours prior to sexual activity. Should your physician determine that the initial dosage is inadequate and you can tolerate it without adverse effects, the dosage may be escalated to 60 mg.

Daily consumption of Dapoxetine or exceeding 30 mg within a 24-hour period is not advised as it increases the risk of severe side effects.

Side Effects of Dapoxetine

Common side effects reported among users of this medication may include:

  • Headaches;
  • Excessive sweating;
  • Increased anxiety levels;
  • Dizziness;
  • Visual disturbances like blurred vision;
  • Elevated blood pressure;
  • Feelings of nervousness and confusion;
  • Reduced libido;
  • Irregular or rapid heartbeat;
  • Unusual dreams;
  • Ringing in the ears;
  • Difficulty achieving or maintaining an erection;
  • Gastrointestinal issues such as diarrhea;
  • Nausea and vomiting;
  • Excessive tiredness;
  • Sleepiness;
  • Dry mouth.

Missed Dose and Overdose

Since Dapoxetine is prescribed on an as-needed basis, the likelihood of missing a dose is minimal. However, to prevent the risk of overdose and serious complications, do not increase the prescribed dosage without medical consultation. If overdose is suspected or there is a case of accidental poisoning, seek immediate medical attention by contacting emergency services or a local poison control center.

Interactions

Dapoxetine may interact with various medications and several health conditions. Some key drug interactions include:

  • Acalabrutinib (concurrent use may heighten bleeding risks);
  • Monoamine oxidase inhibitors including Tranylcypromine and Moclobemide;
  • Herbal supplements such as St. John's Wort;
  • Amino acid Tryptophan;
  • Various antidepressants, including Sertraline, Amitriptyline, Paroxetine, Venlafaxine, Escitalopram, Nortriptyline, Doxepin, and Fluvoxamine;
  • Antibiotics like Linezolid, Clarithromycin, Telithromycin, and Erythromycin;
  • Antifungal medication Fluconazole;
  • Analgesics like Tramadol;
  • Antifungals such as Ketoconazole;
  • Anticoagulants like Warfarin;
  • Mood stabilizers like Lithium;
  • Protease inhibitors like Ritonavir;
  • Calcium channel blockers, including Verapamil.

Health conditions that may interact with Dapoxetine include:

  • Glaucoma, where there is a risk of increased intraocular pressure. Caution is advised in individuals with this condition to mitigate side effects that might impair vision or lead to blindness.
  • Chronic kidney disease, as Dapoxetine is predominantly eliminated through renal pathways. Patients with mild to moderate renal impairment must use this medication cautiously to avoid accumulation and increased serum levels of the drug.
  • Active depression;
  • Severe liver dysfunction;

Combining Dapoxetine with grape juice may enhance the drug's concentration in blood plasma beyond desired levels.

Storage

Dapoxetine must be stored in a cool, dry location, out of the reach of children and pets, to maintain its efficacy and safety.