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Is 20 mg an Effective Dose of Sildenafil? | Ro

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Sildenafil 20 mg, a dosage that is officially approved for the treatment of pulmonary arterial hypertension (PAH), also carries the important distinction of being prescribed to help manage erectile dysfunction (ED). The active ingredient in the well-known brand Viagra, sildenafil, is commonly available in higher doses of 25 mg, 50 mg, or 100 mg. However, healthcare professionals might opt for sildenafil 20 mg as a prudent starting point for treating erectile dysfunction if a lower dosage is deemed more appropriate for the individual's specific health needs. By initiating treatment with the 20 mg dosage, healthcare providers can ascertain how well the patient responds to the medication while minimizing the risk of any potential adverse effects associated with higher dosages.

In the ensuing sections, we will delve deeper into whether sildenafil 20 mg is the right therapeutic approach for you and explore its various implications.

What is sildenafil 20 mg?

Characterized under the brand name Revatio, sildenafil is conventionally prescribed for pulmonary arterial hypertension (PAH). This medication exerts its therapeutic effects by relaxing blood vessels and thereby enhancing blood circulation throughout the body. This increased blood flow mechanism provides a dual benefit, enabling sildenafil to also effectively address erectile dysfunction by facilitating better blood flow to the penis. Improved circulation leads to harder, more sustainable erections, ultimately contributing to a more fulfilling sexual experience.

The Food and Drug Administration has sanctioned sildenafil 20 mg for the treatment of PAH while also approving 25 mg, 50 mg, and 100 mg dosages for managing erectile dysfunction. Since sildenafil is the active ingredient in Viagra, this lower dosage can be prescribed off-label for ED treatment (DailyMed, 2020).

Why use sildenafil 20 mg?

When your healthcare provider is considering the use of sildenafil for erectile dysfunction, the conventional starting dose is typically set at 50 mg. However, it is crucial to understand that this dosage does not guarantee effectiveness for every patient, as individual responses can vary significantly. In cases where a higher dose presents an increased likelihood of experiencing side effects, clinicians may turn to the 20 mg formulation of sildenafil to provide a tailored treatment experience for their patients. The availability of sildenafil in this 20 mg dosage allows for a refined approach, enabling providers to customize the patient's treatment regimen based on their unique response level.

Furthermore, the financial aspect of medical prescriptions plays a significant role in treatment decisions. The brand name Viagra carries a hefty price tag, often costing patients over $70 per dose. Conversely, opting for the generic formulation of sildenafil can substantially reduce out-of-pocket expenses, and utilizing the 20 mg dosage format of generic Revatio could represent an even more economical choice for patients concerned about their budget.

Considering the benefits of sildenafil 20 mg, here are a few key reasons why patients might prefer starting at this dosage rather than utilizing the 25 mg option:

  • Your healthcare provider might choose to initiate treatment at 20 mg to gauge your body's response level to the medication.

  • Some patients may experience side effects when taking higher doses such as 25 mg or 50 mg, whereas they might tolerate the 20 mg or 40 mg doses with minimal or no adverse reactions.

  • In cases where 50 mg proves insufficient, you and your healthcare provider may collaborate to determine that a marginally higher dose, such as 60 mg, would yield better results.

As a general guideline, sticking to the lowest effective dose of a medication is advisable to mitigate the risk of potential side effects. Utilizing sildenafil in 20 mg increments allows healthcare professionals to more accurately pinpoint the dosage that aligns best with the patient's individual requirements, thereby maximizing the therapeutic benefits while keeping side effects to a minimum.

Sildenafil 20 mg: How long does it last?

Typically, sildenafil begins to take effect approximately 30–60 minutes after ingestion and generally remains effective for around four hours. Consequently, individuals are advised to plan their activities accordingly. It’s important to note that sildenafil does not produce an immediate erection; rather, it enhances your ability to achieve and maintain one when sexually aroused (Smith, 2022).

If you have taken sildenafil and find that it doesn’t produce the desired effects, refrain from taking another dose within a 24-hour period. If the prescribed dosage proves ineffective in meeting your needs, it’s advisable to discuss potential adjustments, whether it be a higher dosage or an alternative medication, with your healthcare provider.

Viagra alternatives

Though Viagra is widely recognized as an effective treatment for erectile dysfunction, several alternative medications are available that may present more beneficial options for certain individuals. Alternative ED treatments include:

  • Vardenafil (brand name Levitra)

  • Tadalafil (brand name Cialis)

  • Avanafil (brand name Stendra)

Sildenafil and these other ED medications function as PDE5 inhibitors. They operate by inhibiting an enzyme known as phosphodiesterase type 5 (PDE5), which effectively acts as an "off switch" for erections. The natural chemical responsible for triggering erections is cGMP, which signals blood vessels in the penis to dilate and fill with blood, thus facilitating erections. When PDE5 is inhibited, the dilation of blood vessels in the penis is sustained, leading to prolonged and stronger erections (Dhaliwal, 2022).

It is essential to recognize that although all PDE5 inhibitors work on the same biochemical pathway, they do not function identically. For instance, sildenafil typically takes about 30 minutes to begin working and lasts for approximately 4 to 5 hours. In contrast, avanafil can be taken just 15 minutes prior to sexual activity, with a similar duration of effectiveness as sildenafil. Tadalafil, on the other hand, can be prescribed in two formulations: one for daily use and the other as needed, with a prolonged effect lasting up to 36 hours.

Choosing the most suitable medication for your situation may require ongoing dialogue with your healthcare professional. If you find that your current medication is not yielding the desired results, it is crucial to communicate this to your provider. A well-tailored medication and dosage can significantly enhance your sexual health and satisfaction.

What causes ED?

Erectile dysfunction (ED)—defined as the inability to attain or sustain an erection sufficient for satisfying sexual performance—is recognized as the most prevalent sexual dysfunction affecting men. Research indicates that approximately 30–50 million American men have encountered ED at some point in their lives. While ED can manifest at any age, its incidence rises with advancing age. At the age of 40, a man faces a 40% likelihood of having experienced ED, with this probability escalating by 10% for each subsequent decade (Sooriyamoorthy, 2022; Ferrini, 2017).

Nevertheless, it is vital to clarify that ED is not an inevitable aspect of aging. Various underlying health conditions can contribute to the development of ED, and addressing these conditions often leads to improvements in erectile function. Contributing factors to ED include:

  • Heart disease

  • Diabetes

  • High blood pressure

  • High cholesterol

  • Low testosterone

  • Nerve damage

  • Depression

  • Sleep apnea

Thus, recognizing and addressing the potential health issues contributing to ED is essential. Seeking guidance from a healthcare professional at the first signs of erectile dysfunction is crucial. They will conduct a thorough evaluation of your medical history, assess your overall well-being, and help identify any health concerns that may be impacting your erectile function, allowing you to receive appropriate treatment.

How to get Viagra (sildenafil)

While Viagra (sildenafil) is not available over the counter, a consultation with a healthcare provider—either in-person or online—can lead to a prescription. Discreet mail delivery options for Viagra access are more accessible than ever, addressing the privacy concerns of many patients.

When ordering sildenafil online, caution is paramount. Beware of counterfeit medications that often flood the internet. You may have encountered an array of pop-up ads offering Viagra at suspiciously low prices. Unfortunately, many of these sources are illegitimate and the products they sell can pose genuine risks to your health.

A 2011 investigation conducted by Pfizer, the manufacturer of Viagra, revealed that counterfeit pills bought online contained a variety of harmful substances, including blue printer ink, stimulants like amphetamines, the antibiotic metronidazole, uneven amounts of the active ingredient sildenafil, and even drywall (Pfizer, n.d.).

Side effects and warnings

As with any medication, sildenafil, including its various formulations, can lead to a range of side effects. Commonly reported side effects involve headache, facial flushing, nasal congestion, gastrointestinal discomfort, back pain, and, in rare instances, temporary alterations in color vision. Should you encounter vision disturbances, experience chest pain, or endure priapism—characterized by an erection lasting more than four hours—it is imperative to seek medical assistance without delay.

Moreover, it’s crucial to understand that sildenafil, along with other PDE5 inhibitors, should never be combined with nitrates or nitrites. These substances include certain prescription medications intended for chest pain and recreational drugs commonly referred to as poppers. The concomitant use of sildenafil and nitrates can result in dangerously low blood pressure levels, which may be life-threatening.

If you are interested in exploring sildenafil as a treatment for erectile dysfunction, setting up an appointment with your healthcare provider is a critical first step. Your provider will guide you in selecting the most suitable medication and dosage tailored to your individual health needs.

DISCLAIMER

If you have any medical questions or concerns, please consult your healthcare provider. The articles on Health Guide are grounded in peer-reviewed research and information obtained from reputable medical societies and governmental institutions. Nonetheless, they should not replace professional medical advice, diagnosis, or treatment.

  • Barnett, C. F. & Machado, R. F. (2006). Sildenafil in the treatment of pulmonary hypertension. Vascular Health and Risk Management, 2 (4), 411–422. doi: 10.2147/vhrm.2006.2.4.411. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994020/

  • DailyMed. (2020). SILDENAFIL tablet. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=15372a7c-2935-48dc-a55a-8966719b50be

  • Dhaliwal. A. & Gupta, M. (2022). PDE5 inhibitors. StatPearls. Retrieved on Dec. 14, 2022 from https://www.ncbi.nlm.nih.gov/books/NBK549843/

  • Eardley, I., Ellis, P., Boolell, M., & Wulff, M. (2002). Onset and duration of action of sildenafil for the treatment of erectile dysfunction. British Journal of Clinical Pharmacology, 53. doi: 10.1046/j.0306-5251.2001.00034.x. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874251/

  • Ferrini, M. G., Gonzalez-Cadavid, N. F., & Rajfer, J. (2017). Aging related erectile dysfunction-potential mechanism to halt or delay its onset. Translational Andrology and Urology, 6 (1), 20–27. doi: 10.21037/tau.2016.11.18. Retrieved from https://tau.amegroups.com/article/view/13319/13808

  • Nunes, K. P., Labazi, H., & Webb, R. C. (2012). New insights into hypertension-associated erectile dysfunction. Current Opinion in Nephrology and Hypertension, 21 (2), 163–170. doi: 10.1097/mnh.0b013e32835021bd. Retrieved from https://pubmed.ncbi.nlm.nih.gov/22240443/

  • Pfizer. (n.d.). Viagra: Avoid counterfeits. Retrieved on Dec. 14, 2022 from https://www.viagra.com/avoid-counterfeits

  • Smith, B. P. & Babos, M. (2022). Sildenafil. StatPearls. Retrieved on Dec. 14, 2022 from https://www.ncbi.nlm.nih.gov/books/NBK558978/

  • Sooriyamoorthy, T. & Leslie, S. W. (2022). Erectile dysfunction. StatPearls. Retrieved on Dec. 14, 2022 from https://www.ncbi.nlm.nih.gov/books/NBK562253/