pronounced as (tah da' la fil)
Tadalafil (Cialis) is primarily utilized for the treatment of erectile dysfunction (ED), which is the inability to achieve or maintain an erection suitable for sexual intercourse. Additionally, Tadalafil addresses symptoms related to benign prostatic hyperplasia (BPH), a condition characterized by an enlarged prostate where men may encounter various urinary difficulties, such as hesitancy, dribbling, weak urine stream, the sensation of incomplete bladder emptying, discomfort during urination, and frequent urges to urinate. Furthermore, Tadalafil (Adcirca) is prescribed to enhance exercise capacity in individuals suffering from pulmonary arterial hypertension (PAH), which is a complication involving elevated blood pressure in the vessels that supply blood to the lungs, leading to symptoms like breathlessness, dizziness, and fatigue. The medication belongs to a category known as phosphodiesterase (PDE) inhibitors and functions to improve erectile dysfunction by promoting increased blood flow to the penis during sexual arousal, ultimately facilitating an erection. In the clinical context of PAH, Tadalafil operates by relaxing pulmonary blood vessels, thus easing the flow of blood.
It is crucial to note that even though Tadalafil is effective in managing erectile dysfunction, it does not serve as a cure, nor does it amplify sexual desire. Additionally, it does not act as a contraceptive nor does it safeguard against sexually transmitted infections, including the human immunodeficiency virus (HIV).
Tadalafil is administered as an oral tablet. It can be consumed with or without food, allowing flexibility in its usage.
For those taking Tadalafil to manage erectile dysfunction, adherence to your healthcare provider's instructions is essential. There exist two primary regimens for Tadalafil intake: daily administration or on an as-needed basis. It is advisable to consult your physician regarding the most suitable dosing schedule tailored to your needs. When taken as needed, Tadalafil should be ingested approximately 30 minutes before engaging in sexual activities and should not be used more than once within a 24-hour window. Your physician will provide recommendations on the optimal time for consumption prior to sexual activity. Conversely, Tadalafil may also be taken daily without consideration of sexual timing, permitting attempts at sexual activity at any moment between doses. Consistency is key; if taken regularly, aim to ingest it at the same time each day. Should you possess certain health conditions or be on specific medications, your doctor may recommend modifications to your Tadalafil regimen, adjusting either the frequency or dosage accordingly. Precise adherence to the instructions on your prescription label is critical, and clarification should be sought from your physician or pharmacist regarding any uncertainties. It is imperative to take Tadalafil strictly as prescribed; do not modify your dosage or frequency without consulting your healthcare provider first.
If your treatment involves Tadalafil for PAH or BPH, it’s important to follow your physician's specific directions regarding dosage. Typically, Tadalafil is administered once daily, and all tablets for a given day should be ingested simultaneously; do not divide dosages. Again, taking Tadalafil at a consistent time each day enhances effectiveness. If you are being treated for BPH with other medications, your doctor may instruct you to cease those treatments at least one day prior to initiating Tadalafil therapy. Adhering meticulously to your healthcare provider’s guidance is imperative, and any points of confusion should be directed to them for clarification.
When using Tadalafil for erectile dysfunction, it is common for doctors to commence treatment with a standard dose that may later be adjusted based on your response to the medication. Communicate openly with your healthcare provider if the treatment does not yield expected results or if you face any adverse effects.
It is critical to understand that while Tadalafil may regulate symptoms associated with PAH, it does not offer a definitive cure for the condition. Consistent use of Tadalafil is recommended even if you start feeling better. Avoid discontinuing use without prior discussion with your healthcare provider.
For additional information, please request a copy of the manufacturer’s patient information from your pharmacist or doctor.
This medication may have additional applications; consult your healthcare provider or pharmacist for more details.
Before taking Tadalafil,
- Inform your doctor and pharmacist of any known allergies to Tadalafil, other medications, or any components included in Tadalafil tablets. Consult your pharmacist for a detailed ingredient list.
- Disclose if you are currently taking or have recently used riociguat (Adempas) or nitrates such as isosorbide dinitrate (Isordil), isosorbide mononitrate (Monoket), and nitroglycerin (various formulations). Nitrate medications are available in forms such as tablets, sublingual tablets, sprays, patches, pastes, and ointments. If you are unsure whether any of your medications contain nitrates, ask your physician. You will likely be advised against Tadalafil if already using nitrates.
- Notify your doctor if you use street drugs that contain nitrates, commonly referred to as 'poppers', such as amyl nitrate, butyl nitrate, or nitrite, particularly when taking Tadalafil. Use of Tadalafil while on these substances is typically not recommended.
- Be aware that Tadalafil is marketed under the brand names Adcirca and Cialis; you should be treated with only one of these at any given time.
- Communicate with your healthcare provider and pharmacist regarding any other prescription or nonprescription medications, vitamins, or dietary supplements you are currently taking or planning to use. Ensure to mention any medications including but not limited to alpha blockers, certain antifungals, and various other medications affecting blood pressure, heart rhythm, or overall health. Your physician may adjust your treatment doses or closely monitor you for adverse reactions.
- Inform your doctor regarding any herbal supplements you are using, especially St. John's wort.
- Let your physician know about your smoking habits, if you have previously experienced an erection lasting longer than four hours, or if you have recently had instances of dehydration due to diarrhea, vomiting, inadequate fluid intake, or excessive sweating. Additionally, alert your doctor about any history of pulmonary veno-occlusive disease (PVOD), conditions altering the architecture of the penis, diabetes, cholesterol abnormalities, blood pressure irregularities, heart conditions, strokes, and any blood disorders.
- If you are a female taking Tadalafil for PAH, inform your doctor about any pregnancy status or plans to become pregnant, and whether you are breast-feeding. If pregnancy occurs while on Tadalafil, contact your healthcare provider promptly.
- If undergoing any surgical procedures, including dental work, disclose your Tadalafil usage to your physician or dentist.
- Discuss alcohol consumption with your doctor during Tadalafil therapy. Excessive alcohol intake may heighten the risk of specific side effects associated with Tadalafil, including symptoms such as dizziness, headaches, irregular heartbeat, or hypotension.
- For those using Tadalafil for erectile dysfunction, notify your healthcare provider if you have been previously advised to avoid sexual activities for health reasons or if you have experienced chest pain during sexual endeavors. Engaging in sexual activities can prove taxing on the cardiovascular system, particularly in the presence of heart disease. Seek immediate medical attention if you notice chest pain, dizziness, or nausea during sexual activity.
- Ensure all healthcare providers are aware that you are on Tadalafil, particularly if emergency treatment for heart conditions is required; they must be informed of your last dosage.
Consult with your healthcare provider regarding the consumption of grapefruit and grapefruit juice while on this medication.
If you are on Tadalafil for erectile dysfunction following a prescribed schedule and miss a dose, administer it as soon as you remember. If it's nearing the time for your next dosage, forgo the missed dose and resume your usual schedule. Avoid doubling up on doses or consuming more than one dose daily to compensate.
For Tadalafil prescribed for PAH or BPH, if you miss a dose, take it as soon as you recall. Similarly, if it’s close to your next scheduled dose, skip the missed dose and return to your regular dosing plan. Do not double your dosage.
Tadalafil may manifest various side effects. It is essential to inform your doctor if any of the following symptoms become severe or persist:
- Headache
- Indigestion or heartburn
- Nausea
- Diarrhea
- Flushing
- Discomfort in the stomach, back, muscles, arms, or legs
- Cough
Some side effects necessitate immediate medical attention. If you experience any of the following symptoms, contact your physician promptly or seek emergency medical help:
- Sudden vision loss or decrease (further information provided below)
- Blurred vision
- Alterations in color perception (e.g., seeing a blue tint or difficulty distinguishing between blue and green)
- Sudden hearing loss or decrease (further information below)
- Tinnitus
- An erection lasting beyond 4 hours
- Dizziness
- Chest pain
- Hives
- Skin rash
- Difficulty breathing or swallowing
- Swelling in the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
- Severe skin reactions like blistering or peeling
There have been reports of patients experiencing sudden vision loss either partially or completely after administration of Tadalafil or associated medications. In certain instances, this loss was irreversible. The specific cause of vision loss remains undetermined. If sudden vision loss occurs while on Tadalafil, you must contact your doctor immediately and refrain from taking further doses of Tadalafil or comparable medications such as sildenafil (Revatio, Viagra) or vardenafil (Levitra) until consulting with a healthcare professional.
Similarly, some patients report experiencing a sudden decrease or loss of hearing following Tadalafil intake or other similar medications. This hearing loss often affects one ear and may not recover following cessation of the medication. The specific relationship between the medication and hearing loss has not been clearly established. Should you notice sudden hearing loss, potentially accompanied by tinnitus or dizziness, reach out to your doctor without delay. Avoid taking additional doses of Tadalafil or similar medications until you have consulted your healthcare provider.
Other adverse reactions may arise while using Tadalafil. If any abnormal symptoms present themselves during your treatment, contact your physician.
In case of severe side effects, you or your healthcare provider can report these events to the Food and Drug Administration (FDA) via the MedWatch Adverse Event Reporting program online at https://www.fda.gov/Safety/MedWatch or by calling 1-800-332-1088.
Keep Tadalafil stored in its original container, securely closed, and out of reach of children. It should be maintained at room temperature, protected from excessive heat and moisture, and not stored in a bathroom.
Unused medications should be disposed of appropriately to prevent accidental ingestion by pets, children, or others. However, do not flush this medication down the toilet. The preferred method of disposal is through a medication take-back program. Consult your pharmacist or local waste management authority to find out about take-back programs available within your area. For more disposal guidance, see the FDA's Safe Disposal of Medicines website at https://goo.gl/c4Rm4p.
Always ensure that medications are kept out of sight and reach of children. Various containers, including those for eye drops, creams, patches, and inhalers, may not be child-resistant, presenting a risk to young children. To prevent poisonings, always secure safety caps and promptly place medications in a safe storage area that is inaccessible to children, ensuring that they are kept high and out of their line of sight and reach. For more information on safe storage practices, visit https://www.upandaway.org.
If an overdose is suspected, contact the poison control center at 1-800-222-1222. Additional information can be obtained online at https://www.poisonhelp.org/help. In cases where the individual has collapsed, suffered a seizure, is experiencing respiratory difficulties, or cannot be awakened, immediate emergency medical assistance should be sought by calling 911.
It is important to attend all scheduled appointments with your healthcare provider.
Do not allow anyone else to use your medication. Should you have any questions about refilling your prescription, do not hesitate to ask your pharmacist.
Maintaining a detailed list of all prescription and over-the-counter (OTC) medications you are taking, along with any supplementary products like vitamins and minerals, is vital. Bring this list whenever visiting a healthcare provider or when admitted to a hospital. This information is also crucial to carry in the event of an emergency.
- Adcirca®
- Cialis®
- Entadfi® (as a combination product containing Finasteride, Tadalafil)