Tadalafil: Uses, Dosage, Side Effects, Warnings

Tadalafil is the active ingredient in the brand-name medication Cialis®, primarily prescribed for the treatment of erectile dysfunction (ED) and also used to alleviate the symptoms associated with benign prostatic hyperplasia (BPH). It functions by relaxing the blood vessels, thus enhancing blood flow to specific areas of the body, especially the penis. As approved by the FDA, tadalafil has similar benefits and risks as its brand name counterpart Cialis.

This medication is renowned for its remarkable longevity, enabling effects to be felt for up to 36 hours post-ingestion. This extended time frame allows for increased spontaneity in sexual activities, an attractive feature for many users. Typically, tadalafil is consumed on an as-needed basis; however, a lower-dose daily prescription option is available for those seeking continuous management of symptoms.

While tadalafil can be highly effective, it’s essential to be aware of common side effects, which may include headaches, indigestion, back pain, and muscle aches. Most of these effects usually subside within a few days. Users with pre-existing cardiovascular conditions should be particularly cautious when using Cialis due to potential risks, especially if they are also taking nitrates or specific other medications that may interact adversely with tadalafil.

Cialis (tadalafil) is clinically indicated for the treatment of the following conditions:

• Erectile dysfunction (ED)

• The signs and symptoms of benign prostatic hyperplasia (BPH)

• Combined treatment of ED and the signs and symptoms of BPH (ED/BPH)

The medication tadalafil belongs to the class of drugs known as phosphodiesterase-5 (PDE5) inhibitors, which specifically target the enzyme responsible for regulating blood flow in the penis.

Common adverse reactions associated with tadalafil, occurring in at least 2% of users, include but are not limited to:

• Headache

• Indigestion

• Back pain

• Muscle pain

• Nasal congestion

• Flushing

• Pain in limbs

• The administration of Cialis is strictly contraindicated for patients who are also using any form of organic nitrates.

• A history of serious hypersensitivity reactions to either Cialis or Adcirca

• Potential drug interactions include nitrates, alpha blockers, antihypertensives, alcohol, as well as CYP3A4 inhibitors (such as ketoconazole and ritonavir) and inducers (like rifampin).

• Painstaking care should be taken by patients not to use Cialis when sexual activity is inadvisable due to cardiovascular health considerations.

• The concurrent use of Cialis with alpha blockers, antihypertensives, or significant quantities of alcohol (≥5 units) can lead to dangerously low blood pressure.

• It is advisable to avoid combining Cialis with alpha blockers for managing BPH, given that the safety and efficacy of this combination have not been adequately explored, and there lies a heightened risk of hypotensive effects.

• If a patient is concurrently taking potent inhibitors of CYP3A4, a dosage adjustment may be necessary to ensure safety and effectiveness.

• Any patient experiencing an erection lasting longer than 4 hours should immediately seek medical assistance.

• Should there be a sudden loss of vision in one or both eyes, the patient must discontinue use of Cialis and seek prompt medical care, as this could indicate non-arteritic ischemic optic neuropathy (NAION).

• Patients should also be vigilant for any sudden decrease in hearing or onset of hearing loss, and medical attention should be sought immediately in such instances.

• Before commencing treatment with Cialis for BPH, it is crucial to evaluate other urological conditions that may mimic similar symptoms.

Currently, there is no boxed warning available for Tadalafil.

The cost of tadalafil can vary widely depending on several factors, including your insurance coverage, the prescribed dosage, quantity, and the pharmacy from which it is purchased. Without insurance, the average price ranges from $1 to $25 per tablet. Patients may find coupons and discount cards helpful for reducing costs, and some insurance plans may cover part or all of the expenses associated with the drug.

If you are considering tadalafil through Hims, the online platform offers treatments for erectile dysfunction (ED) starting at approximately $40 per month. Additionally, Hims provides access to chewable Hard Mints, which may contain tadalafil and/or sildenafil, beginning at $1.63 per use. These mints are compounded medications, prescribed by licensed healthcare providers and manufactured in licensed, FDA-compliant pharmacies, although they have not received specific FDA approval.

For those considering alternatives to tadalafil, numerous other medications are available for the treatment of both ED and BPH. It is critical to consult with a healthcare provider who can offer insights into which alternatives may be more suitable based on individual health circumstances.

Other commonly prescribed oral medications for ED include:

• Viagra® (sildenafil)

• Cialis® (tadalafil)

• Stendra® (avanafil)

• Vardenafil

• Chewable ED medications available via Hims, containing one or more of the active ingredients found in Cialis and Viagra

Penile injection medications designed for ED include:

• Caverject® or Edex® (alprostadil)

• Papaverine

• Phentolamine

• Combination medications, such as Bimix, Trimix, and Quadmix

Your healthcare provider may also recommend psychotherapy for mental health conditions affecting ED and lifestyle alterations conducive to improved sexual health, including diet modifications, regular exercise, and reduced alcohol intake.

Other recognized treatments for ED may involve topical gels, penis pumps (with or without constriction rings), penile implant surgery, and testosterone therapy, particularly if low testosterone levels are contributing to the condition.

BPH Management Options

For managing benign prostatic hyperplasia (BPH), alternative treatments include:

• 5-alpha reductase inhibitors:

  • Avodart® (dutasteride)

  • Proscar® (finasteride)

• Alpha-blockers:

  • Uroxatral® (alfuzosin)

  • Cardura® (doxazosin)

  • Rapaflo® (silodosin)

  • Flomax® (tamsulosin)

  • Terazosin

• Combination therapies

• Surgical interventions

How quickly does tadalafil work?

Tadalafil typically begins to work within approximately 30 minutes to two hours after consumption, provided there is sexual stimulation.

What are the available dosages of tadalafil?

Tadalafil can be prescribed for either daily use or as needed. The daily regimen typically involves a lower dose (2.5 or 5 mg), to be taken once a day. When prescribed for on-demand use for ED, the typical dosage ranges from 5 mg to 20 mg, and it is recommended to take it about two hours prior to planned sexual activity.

How long does tadalafil last?

Tadalafil remains effective for a duration of up to 36 hours post-ingestion, making it one of the longest-lasting medications available for ED treatment.

Is tadalafil the same as Cialis®?

Tadalafil is the active component found in Cialis. Research indicates that both are equally effective in treating ED, sharing similar durations of efficacy and side effect profiles. The primary distinction lies in the fact that Cialis is a brand name, typically leading to a higher price point compared to generic tadalafil.

A prescription for tadalafil can be obtained following an evaluation by your primary care physician or a specialist who can assess if this medication is appropriate based on your symptoms and medical history.

Hims offers access to both daily and as-needed tadalafil treatments for eligible patients. Their service connects you to a healthcare provider who will review your symptoms and medical history. Upon approval for treatment, your prescription will be sent in discreet packaging and should arrive within a few days.

This article is intended for informational purposes only and should not be considered medical advice. The information provided herein is not a substitute for professional medical counsel. Always consult with your healthcare provider about the risks and benefits of any treatment. To further explore our editorial standards, click here.

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